Breast Cancer Research Foundation (BCRF) Initiative: Addressing Disparities in Breast Cancer Treatment and Outcomes for Black Women
BCRF’s Ongoing Research Efforts
BCRF recognizes the continued need for more research to end disparities faced by Black women across the U.S. A snapshot of the current BCRF-supported projects specifically in this area includes:
Immune Cell Study
Drs. Christine Ambrosone and Chi-Chen Hong are studying the types of immune cells found in and around breast tumors from both Black and white women to determine if they affect tumor aggressiveness.
Inherited Mutations in Breast Cancer Susceptibility Genes
Dr. Fergus Couch has identified inherited mutations in breast cancer susceptibility genes that confer an increased risk of TNBC and may be important for screening in high-risk Black women. His team examined gene mutations in a large, racially diverse population of American women. This study showed that mutations in the BARD1, RAD51C, and RAD51D genes, while very uncommon, appear more frequently in Black women with breast cancer and are associated with an increased risk of both TNBC and estrogen receptor (ER)–negative breast cancer.
Relationships Between Social Determinants of Health, Ancestry, Tumor Micro-Environment, and Survival
In a cohort of 100 breast cancer patients with African ancestry, Dr. Melissa Davis is studying the relationships between social determinants of health, ancestry, the tumor micro-environment, and survival.
Immunological Features of Breast Cancers in Black Women
Dr. Laura Esserman is examining the immunological features of breast cancers in Black women to gain a better understanding of the spectrum of disease and the types of interventions that might improve outcomes.
Neighborhood Factors and Stress on Breast Cancer Tumor Microenvironment
Dr. Neha Goel is evaluating how neighborhood factors and stress may affect the breast cancer tumor microenvironment in diverse populations.
Mitigating Unconscious Bias in Clinical Trials
Recognizing that access to clinical trials that test new therapies is vital to Black women’s survival, Dr. Carmen Guerra is investigating ways to mitigate unconscious bias that may decrease their enrollment.
Underrepresented Populations in Breast Cancer Research
In her BCRF project, Dr. MacGregor is looking at underrepresented or understudied populations, including racial and ethnic minorities as well as older people, and evaluating the rates of treatment completion and how treatment-related toxicities and access to care impact these groups.
Differences in Immune Pathway Activation Between Black and White Women with Breast Cancer
Dr. Kathy Miller is identifying differences in immune pathway activation between Black and white women with breast cancer in order to exploit any unique biologic vulnerabilities inherent in Black women’s tumors to improve outcomes.
Pilot Study on Breast Cancer Disparities and Physician Engagement
Dr. Lisa Newman is conducting a pilot study to both tackle breast cancer disparities related to race and ethnicity and to provide a platform for Black physicians to be more engaged in research.
Genetic Factors Responsible for TNBC and Black Women’s Higher Incidence
Drs. Olufunmilayo (Funmi) Olopade and Dezheng Huo are identifying genetic factors responsible for TNBC and those that specifically predispose Black women to this aggressive disease. Dr. Olopade and colleagues were the first to discover that Black women have a higher incidence of mutations in the BRCA1 and BRCA2 genes—as well as other inherited susceptibility genes—compared to their white counterparts.
Differences in Genes and Gene Mutations in Black Women’s Breast Tumors
Work led by Dr. Charles Perou and BCRF collaborators has uncovered differences in the genes and gene mutations found in Black women’s breast tumors compared to those in white women. His team is building on their findings to identify the drivers of metastatic disease, determine the adaptive immune system’s role in breast tumor progression, and improve therapeutic targeting of TNBC tumors to decrease disparities in outcomes.
Relationship Between Race and Treatment Response Biomarkers in TNBC
Utilizing data from completed and ongoing clinical trials, Dr. Priyanka Sharma is studying the relationship between race and treatment response biomarkers in TNBC. Ultimately, her research will move us closer to personalized medicine, tailoring treatments to an individual’s cancer biology.
Conclusion
BCRF’s ongoing research initiatives aim to address the significant disparities in breast cancer treatment and outcomes for Black women. By understanding the underlying causes of these disparities, researchers can develop targeted interventions to improve prevention, detection, and treatment outcomes for Black women.
Frequently Asked Questions (FAQs)
* What is the goal of BCRF’s breast cancer research initiatives?
– To address the significant disparities in breast cancer treatment and outcomes for Black women.
* Which BCRF-supported projects aim to investigate genetic factors responsible for TNBC and Black women’s higher incidence?
– Drs. Olufunmilayo (Funmi) Olopade and Dezheng Huo are leading studies on this topic.
* What is the focus of Dr. Priyanka Sharma’s research on the relationship between race and treatment response biomarkers in TNBC?
– Her research aims to develop personalized medicine approaches for individuals with TNBC, tailoring treatments to their unique cancer biology.